Punit P. Seth: search on Z-Library

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1

The Medicinal Chemistry of Therapeutic Oligonucleotides

Wan, W. Brad, Seth, Punit P.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.27 MB

english, 2016

2

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice

Shemesh, Colby S., Yu, Rosie Z., Gaus, Hans J., Seth, Punit P., Swayze, Eric E., Bennett, Frank C., Geary, Richard S., Henry, Scott P., Wang, Yanfeng

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2016

Language:

english

File:

PDF, 806 KB

english, 2016

3

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′ O -Methoxyethyl and 2′,4′-Constrained 2′ O -Ethyl Nucleic Acid Analogues

Seth, Punit P., Vasquez, Guillermo, Allerson, Charles A., Berdeja, Andres, Gaus, Hans, Kinberger, Garth A., Prakash, Thazha P., Migawa, Michael T., Bhat, Balkrishen, Swayze, Eric E.

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

4

Single-Stranded siRNAs Activate RNAi in Animals

Lima, Walt F., Prakash, Thazha P., Murray, Heather M., Kinberger, Garth A., Li, Wenyu, Chappell, Alfred E., Li, Cheryl S., Murray, Susan F., Gaus, Hans, Seth, Punit P., Swayze, Eric E., Crooke, Stanle

Journal:

Year:

2012

Language:

english

File:

PDF, 1.64 MB

english, 2012

5

Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver

Miller, Colton M., Tanowitz, Michael, Donner, Aaron J., Prakash, Thazha P., Swayze, Eric E., Harris, Edward N., Seth, Punit P.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2018

Language:

english

File:

PDF, 746 KB

english, 2018

6

Synthesis and biological evaluation of sialyl-oligonucleotide conjugates targeting leukocyte B trans-membranal receptor CD22 as delivery agents for nucleic acid drugs

St-Pierre, Gabrielle, Pal, Sudip, Østergaard, Michael E., Zhou, Tianyuan, Yu, Jinghua, Tanowitz, Michael, Seth, Punit P., Hanessian, Stephen

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.61 MB

english, 2016

7

SAR by MS: Discovery of a New Class of RNA-Binding Small Molecules for the Hepatitis C Virus: Internal Ribosome Entry Site IIA Subdomain

Seth, Punit P., Miyaji, Alycia, Jefferson, Elizabeth A., Sannes-Lowery, Kristin A., Osgood, Stephen A., Propp, Stephanie S., Ranken, Ray, Massire, Christian, Sampath, Rangarajan, Ecker, David J.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 209 KB

english, 2005

8

Synthesis and Biological Activity of 5‐Fluorotubercidin

Wang, Xiaojing, Seth, Punit P., Ranken, Ray, Swayze, Eric E., Migawa, Michael T.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2004

Language:

english

File:

PDF, 177 KB

english, 2004

9

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

Gaus, Hans J, Gupta, Ruchi, Chappell, Alfred E, Østergaard, Michael E, Swayze, Eric E, Seth, Punit P

Journal:

Nucleic Acids Research

Year:

2018

File:

PDF, 2.05 MB

2018

10

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys

Yu, Rosie Z., Gunawan, Rudy, Post, Noah, Zanardi, Thomas, Hall, Shannon, Burkey, Jennifer, Kim, Tae-Won, Graham, Mark J., Prakash, Thazha P., Seth, Punit P., Swayze, Eric E., Geary, Richard S., Henry,

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2016

Language:

english

File:

PDF, 395 KB

english, 2016

11

Synthesis and biophysical characterization of R-6′-Me-α-l-LNA modified oligonucleotides

Punit P. Seth, Jinghua Yu, Charles R. Allerson, Andres Berdeja, Eric E. Swayze

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 519 KB

english, 2011

12

A general method for deprotection of N-toluenesulfonyl aziridines using sodium naphthalenide

Stephen C. Bergmeier, Punit P. Seth

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 259 KB

english, 1999

13

Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase

Shuanghu Liu, Cassie A. Nelson, Li Xiao, Ling Lu, Punit P. Seth, Darrell R. Davis, Curt H. Hagedorn

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 1.09 MB

english, 2011

14

A Constrained Tricyclic Nucleic Acid Analogue of α- l -LNA: Investigating the Effects of Dual Conformational Restriction on Duplex Thermal Stability

Hanessian, Stephen, Wagger, Jernej, Merner, Bradley L., Giacometti, Robert D., Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.

Journal:

Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

15

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Egli, Martin, Pallan, Pradeep S., Allerson, Charles R., Prakash, Thazha P., Berdeja, Andres, Yu, Jinghua, Lee, Sam, Watt, Andrew, Gaus, Hans, Bhat, Balkrishen, Swayze, Eric E., Seth, Punit P.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 2.96 MB

english, 2011

16

ChemInform Abstract: Synthesis of 1-Oxadecalones via the Lewis Acid Catalyzed Dihydropyrone Diels—Alder Reaction.

Punit P. Seth, Nancy I. Totah

Journal:

Year:

2000

File:

PDF, 32 KB

2000

17

Formation of Scalemic Aziridines via the Nucleophilic Opening of Aziridines

Bergmeier, Stephen C., Seth, Punit P.

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 218 KB

english, 1997

18

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

Seth, Punit P, Jazayeri, Ali, Yu, Jeff, Allerson, Charles R, Bhat, Balkrishen, Swayze, Eric E

Journal:

Molecular Therapy — Nucleic Acids

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

19

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

Miller, Colton M., Donner, Aaron J., Blank, Emma E., Egger, Andrew W., Kellar, Brianna M., Østergaard, Michael E., Seth, Punit P., Harris, Edward N.

Journal:

Nucleic Acids Research

Year:

2016

Language:

english

File:

PDF, 4.75 MB

english, 2016

20

An Unusual Intramolecular Acetal Alkylation

Gao, Xiuchun, Seth, Punit P., Bitok, John K., Totah, Nancy I.

Journal:

Year:

2005

Language:

english

File:

PDF, 93 KB

english, 2005

21

Structure and nuclease resistance of 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-ethyl (cEt) modified DNAs

Pallan, Pradeep S., Allerson, Charles R., Berdeja, Andres, Seth, Punit P., Swayze, Eric E., Prakash, Thazha P., Egli, Martin

Journal:

Chemical Communications

Year:

2012

Language:

english

File:

PDF, 1.50 MB

english, 2012

22

Therapeutic targeting of HCV internal ribosomal entry site RNA

Davis, Darrell R, Seth, Punit P

Journal:

Antiviral Chemistry & Chemotherapy

Year:

2010

Language:

english

File:

PDF, 627 KB

english, 2010

23

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

Østergaard, Michael E., Nichols, Josh, Dwight, Timothy A., Lima, Walt, Jung, Michael E., Swayze, Eric E., Seth, Punit P.

Journal:

Molecular Therapy — Nucleic Acids

Year:

2017

Language:

english

File:

PDF, 3.46 MB

english, 2017

24

IFN-Î³ and CIITA modulate IL-6 expression in skeletal muscle

Adhikari, Abhinav, Cobb, Brittan, Eddington, Seth, Becerra, Nathalie, Kohli, Punit, Pond, Amber, Davie, Judith

Journal:

Year:

2020

File:

PDF, 666 KB

2020

25

Synthesis and Biological Activity of 5-Fluorotubercidin.

Xiaojing Wang, Punit P. Seth, Ray Ranken, Eric E. Swayze, Migawa Michael T. Migawa Michael T.

Journal:

Year:

2004

File:

PDF, 119 KB

2004

26

Structural requirements for hybridization at the 5′-position are different in α-l-LNA as compared to β-d-LNA

Punit P. Seth, Charles R. Allerson, Michael E. Østergaard, Eric E. Swayze

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 429 KB

english, 2012

27

Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver

Donner, Aaron J., Wancewicz, Edward V., Murray, Heather M., Greenlee, Sarah, Post, Noah, Bell, Melanie, Lima, Walt F., Swayze, Eric E., Seth, Punit P.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2017

Language:

english

File:

PDF, 870 KB

english, 2017

28

Endosomal Escape of ASOs Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation

Miller, Colton M., Wan, W. Brad, Seth, Punit P., Harris, Edward N.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2018

Language:

english

File:

PDF, 625 KB

english, 2018

29

An Unusual Intramolecular Acetal Alkylation.

Xiuchun Gao, Punit P. Seth, John K. Bitok, Nancy I. Totah

Journal:

Year:

2005

File:

PDF, 26 KB

2005

30

Efficient solution phase synthesis of 2-(N-acyl)-aminobenzimidazoles

Punit P. Seth, Dale E. Robinson, Elizabeth A. Jefferson, Eric E. Swayze

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 212 KB

english, 2002

31

ChemInform Abstract: The Dihydropyrone Diels—Alder Reaction: Development and Application to the Synthesis of Highly Functionalized 1-Oxa-4-decalones.

Punit P. Seth, Deqi Chen, Junquan Wang, Xiuchun Gao, Nancy I. Totah

Journal:

Year:

2001

File:

PDF, 37 KB

2001

32

The synthesis of γ-amino olefins. A novel intramolecular aziridine — allylsilane reaction

Stephen C. Bergmeier, Punit P. Seth

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 264 KB

english, 1995

33

Identification of 2-Aminobenzimidazole dimers as antibacterial agents

Punit P Seth, Elizabeth A Jefferson, Lisa M Risen, Stephen A Osgood

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

34

Synthesis and biophysical evaluation of 3′-Me-α-l-LNA – Substitution in the minor groove of α-l-LNA duplexes

Punit P. Seth, Charles A. Allerson, Michael E. Østergaard, Eric E. Swayze

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 439 KB

english, 2011

35

Structure-Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angle γ

Prof. Dr. Stephen Hanessian, Dr. Benjamin R. Schroeder, Robert D. Giacometti, Dr. Bradley L. Merner, Michael Østergaard, Eric E. Swayze, Punit P. Seth

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 1023 KB

english, 2012

36

Synthesis and Antisense Properties of 2′- O -(2 S -Methoxypropyl)-RNA-Modified Gapmer Antisense Oligonucleotides

Yu, Jinghua, Pandey, Sanjay K., Khatri, Hetal, Prakash, Thazha P., Swayze, Eric E., Seth, Punit P.

Journal:

Year:

2014

Language:

english

File:

PDF, 757 KB

english, 2014

37

Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity

Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 85 KB

english, 2017

38

The Interaction of Phosphorothioate Containing RNA Targeted Drugs with Proteins is a Critical Determinant of The Therapeutic Effects of These Agents

Crooke, Stanley, Seth, Punit P, Vickers, Timothy A., Liang, Xue-hai

Journal:

Journal of the American Chemical Society

Year:

2020

File:

PDF, 1.44 MB

2020

39

Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-( N -Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′- O ,4′- C -Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Prakash, Thazha P., Siwkowski, Andrew, Allerson, Charles R., Migawa, Michael T., Lee, Sam, Gaus, Hans J., Black, Chris, Seth, Punit P., Swayze, Eric E., Bhat, Balkrishen

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.75 MB

english, 2010

40

Insights from Crystal Structures into the Opposite Effects on RNA Affinity Caused by the S - and R -6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid

Pallan, Pradeep S., Yu, Jinghua, Allerson, Charles R., Swayze, Eric E., Seth, Punit, Egli, Martin

Journal:

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

41

ChemInform Abstract: Synthesis of Bicyclic Proline Analogues Using a Formal [3 + 2] Intramolecular Aziridine—Allylsilane Cycloaddition Reaction.

Stephen C. Bergmeier, Susan L. Fundy, Punit P. Seth

Journal:

Year:

1999

File:

PDF, 32 KB

1999

42

Synthesis, Duplex Stabilization and Structural Properties of a Fluorinated Carbocyclic LNA Analogue

Seth, Punit P., Pallan, Pradeep S., Swayze, Eric E., Egli, Martin

Journal:

Year:

2013

Language:

english

File:

PDF, 939 KB

english, 2013

43

Synthesis and Biophysical Properties of Constrained d -Altritol Nucleic Acids (cANA)

Migawa, Michael T., Prakash, Thazha P., Vasquez, Guillermo, Seth, Punit P., Swayze, Eric E.

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 457 KB

english, 2013

44

Synthesis of 1-Oxadecalones via the Lewis Acid Catalyzed Dihydropyrone Diels−Alder Reaction

Seth, Punit P., Totah, Nancy I.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 64 KB

english, 1999

45

Synthesis and Duplex-Stabilizing Properties of Fluorinated N -Methanocarbathymidine Analogues Locked in the C3′- endo Conformation

Jung, Michael E., Dwight, Timothy A., Vigant, Frederic, Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 522 KB

english, 2014

46

ChemInform Abstract: Synthesis and Biophysical Properties of Constrained D-Altritol Nucleic Acids (cANA).

Migawa, Michael T., Prakash, Thazha P., Vasquez, Guillermo, Seth, Punit P., Swayze, Eric E.

Journal:

Year:

2014

File:

PDF, 22 KB

2014

47

MXD3 antisense oligonucleotide with superparamagnetic iron oxide nanoparticles: A new targeted approach for neuroblastoma

Sakiko Yoshida, MD., Duong, Connie, Oestergaard, Michael, Fazio, Michael, Chen, Cathy, Peralta, Rachael, Guo, Shuling, Seth, Punit P, Li, Yueju, Beckett, Laurel, Nitin, Nitin, Satake, Noriko

Journal:

Nanomedicine: Nanotechnology, Biology and Medicine

Year:

2019

File:

PDF, 8.95 MB

2019

48

Structure-Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angle γ

Prof. Dr. Stephen Hanessian, Dr. Benjamin R. Schroeder, Robert D. Giacometti, Dr. Bradley L. Merner, Michael Østergaard, Eric E. Swayze, Punit P. Seth

Journal:

Angewandte Chemie

Year:

2012

Language:

english

File:

PDF, 1013 KB

english, 2012

49

Biophysical and Biological Characterization of Hairpin and Molecular Beacon RNase H Active Antisense Oligonucleotides

Østergaard, Michael E., Thomas, George, Koller, Erich, Southwell, Amber L., Hayden, Michael R., Seth, Punit P.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 471 KB

english, 2015

50

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

Seth, Punit P., Allerson, Charles R., Berdeja, Andres, Siwkowski, Andrew, Pallan, Pradeep S., Gaus, Hans, Prakash, Thazha P., Watt, Andrew T., Egli, Martin, Swayze, Eric E.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

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